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Abstract
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This work describes the electrochemical behavior of diclofenac on the surface of a
carbonceramic electrode (CCE) modified with multi-walled carbon nanotubes (MWCNT)
and an ionic liquid (IL) composite. The MWCNT-IL composite showed an enhancement
effect in the electro-oxidation of diclofenac with respect to a bare carbon ceramic electrode.
Based on the experimental outcomes, a possible mechanism for the electro-oxidation of
diclofenac is proposed and discussed. Under the optimized experimental conditions, the
MWCNT-IL CCE showed a linear response to diclofenac over the concentration range
50 nM–20 lM with a detection limit of 27 nM. The developed diclofenac sensor showed
good stability, sensitivity, and reproducibility in the measurement of diclofenac in human
blood plasma samples.
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