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Abstract
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A magneticsolidphaseextractionmethodbasedon β-cyclodextrin(β-CD) graftedgrapheneoxide(GO)/
magnetite (Fe3O4) nano-hybridasaninnovativeadsorbentwasdevelopedfortheseparationandpre-
concentration ofgemfibrozil priortoitsdeterminationbyspectrofluorometry.Theas-prepared β-CD/GO/
Fe3O4 nano-hybridpossessesthemagnetismpropertyofFe3O4 nano-particles thatmakesiteasily
manipulated byanexternalmagnetic field. Ontheotherhand,thesurfacemodification ofGOby β-CD
leads toselectiveseparationofthetargetanalytefromsamplematrices.Thestructureandmorphology
of thesynthesizedadsorbentwerecharacterizedusingpowderX-raydiffraction,Fouriertransform
infraredspectroscopy,and field emissionscanningelectronmicroscopy.Theexperimentalfactors
affecting theextraction/pre-concentrationanddeterminationoftheanalytewereinvestigatedand
optimized. Undertheoptimizedexperimentalconditions,thecalibrationgraphwaslinearintherange
between 10and5000pgmL1 with acorrelationcoefficient of0.9989.Thelimitofdetectionand
enrichment factorforgemfibrozil were3pgmL1 and 100,respectively.Themaximumsorption
capacity oftheadsorbentforgemfibrozil was49.8mgg1. Themethodwassuccessfullyappliedto
monitoring gemfibrozil inhumanserumandpharmaceuticalwastewaterssampleswithrecoveriesin
the rangeof96.0–104.0%forthespikedsamples.
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