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Abstract
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Single-walled carbon nanotube-modified carbon–ceramic electrode (SWCNT/CCE) was employed for the
simultaneous determination of acetaminophen (APAP) and ascorbic acid (AA). The SWCNT/CCE displayed
excellent electrochemical catalytic activities toward APAP and AA oxidation compared with bare CCE. In
the differential pulse voltammetry technique, both AA and APAP gave sensitive oxidation peaks at 62
and 302 mV versus saturated calomel electrode, respectively. Under the optimized experimental conditions,
APAP and AA gave linear responses over ranges of 0.2 to 150.0 lM (R2 = 0.998) and 5.0 to 700.0 lM
(R2 = 0.992), respectively. The lower detection limits were found to be 0.12 lM for APAP and 3.0 lM for
AA. The investigated method showed good stability, reproducibility, and repeatability as well as high
recovery in pharmaceutical and biological samples.
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