|
Abstract
|
A new method for one-pot synthesis of Hantzsch 1,4-dihyropyridines was achieved by the reaction of an aromatic aldehyde (benzaldehyde derivatives), a β-dicarbonyl compound (ethyl acetoacetate)and ammonium acetate using a heterogeneous catalyst (imidazolium based hydrogen sulfate ionic liquid) in ethanol. An important advantage of this catalyst is the ease of separating it from the reaction mixture, as well as the fact that it could be recycled a number of times;mild conditions, excellent yield and short reaction time are other advantages of this catalyst as efficient and novel method.The present environmentally benign procedure for the synthesis of 1,4-dihydropyridines is suitable for library synthesis and it will find application in the synthesis of potent biologically active molecules. The excellent yield and extreme rapidity of the method is due to a concurrent effect of the catalyst. All reactions were monitored by TLC, and spectroscopic techniques such as 1HNMR and FT-IR, have been used to identify the products.
|