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Title
Preparation and characterization of cetirizine intercalated layered double hydroxide and chitosan nanocomposites
Type of Research Article
Keywords
Cetirizine,Zn–Allayereddoublehydroxide,Chitosan
Abstract
ThesynthesesandcharacterizationofZn–Allayereddoublehydroxide(LDH)andchitosannanocompositsarereportedinthepresentpaper.Byincreasingchitosanconcentration,thecrystallitegrowthisinhibitedinbothdirectionsaandc.Afterward,cetirizine-intercalatedLDHwassynthesized.AccordingtoXRDpatterns,increaseinbasalspacingindicatedthatcetirizineanionswereintercalatedintoLDH.In-vitrodrugreleaseexperimentshavebeeninvestigated.Onthebasisofthereleaseprofiles,itwasfoundthatincreaseinchitosanconcentrationcausesindecreaseindrugreleaserate.Therefore,chitosanconcentrationcanbeadjustedtocontroltherateofthedrugrelease.
Researchers Kamelia Nejati (First Researcher)، HASSAN KEYPOUR (Second Researcher)، PARVANEH DELIR KHEIROLLAHI NEZHAD (Third Researcher)، Zolfaghar Rezvani (Fourth Researcher)، KARIM ASADPOUR-ZEYNALI (Fifth Researcher)