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Abstract
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In this research work, the antibiotic drug Ciprofloxacin
(CFX) was intercalated into interlayer space of Zn/Al
layered double hydroxides (LDH) by coprecipitation
method and CFX-LDH nanohybride was obtained.
Then, the Alginate/LDH and Chitosan/LDH bionanocomposites
were prepared by coating of CFX-LDH
nanohybride with Alginate and Chitosan. The LDH-CFX
nanohybride and the bionanocomposites were characterized
using the powder X-ray diffraction, the scanning
electron microscope, the thermogravimetric
analyses, and the Fourier transform infrared spectroscopy.
In vitro release behavior of the CFX from LDH
and bionanocomposites is observed in buffer solution
under pH conditions (pH51.2, 6.8, 7.4) which have
been chosen from a model of the passage materials
through the gastrointestinal tract.
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