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Abstract
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Pechmann condensation of phenols with β-ketoesters and 1,3-diketones in presence of a novel ionic liquid bearing multi-HSO4 groups at ambient temperature gave the corresponding coumarin derivatives with high to excellent yields in shorter reaction times. In this work, the efficiency, generality and applicability of new nanosilica based ionic liquid NaHSO4 as heterogeneous and green catalyst for the synthesis of coumarin derivatives from the reaction of phenols and β-ketoesters and 1,3-diketones in water and ethanol (as co-solvent) at room temperature are studied. High yields, relatively short reaction times, efficiency, generality, clean process, simple methodology, low cost, easy work-up, ease of preparation and regeneration of the catalyst and green conditions in the synthesis of coumarins are advantages of the application of nanosilica based ionic liquid NaHSO4 in the above organic reaction.
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