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Keywords
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Silica nanoparticles, Ionic liquid, Imidazole, pH-sensitive, Oral drug delivery.
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Abstract
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The one hand, the N-methylimidazole was covalently attached to the 3-trimethoxysilylpropyl chloride with replacement of all the chlorine atoms. A silica nanoparticle was modified by 1-(3-Trimethoxysilylpropyl)-3-methyl-imidazolium Chloride. On the other hand, Silica-poly(methacrylic acid) (PMA) was successfully prepared via copolymerization of methacrylic acid (PMA) onto vinyl-bond-modified silica NPs. The procedure consisted of surface activation with 3- trimethoxysilyl propyl methacrylate (3-TMSM), followed by free-radical polymerization of methacrylic acid (MAA) in ethyl acetate with 2,2΄-azobis-isobutyronitrile (AIBN) as initiator. Finally, these two systems were mixed together. An anionic drug, naproxen was entrapped in each of these carriers and was dry by freeze drying method. Simulated gastric fluids (SGF, pH=1) and simulated intestinal fluids (SIF, pH=7.4) to determination of in vitro release profiles were stablished in an enzyme-free environment.
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