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Abstract
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High-loading-capacity pH-sensitive glycol
hydrogels were developed using allyl α-D-galactopyranoside
as a biodegradable and biocompatible carbohydrate. These
new pH-sensitive glycol polymers were obtained through the
free-radical polymerization of methacrylic acid and allyl α-Dgalactopyranoside
using 1,6-hexanediol diacrylate and 1,6-
hexanediol propoxylate diacrylate as crosslinker. The novel
sugar-bearing galactopyranoside-based hydrogels were analyzed
to test their hydrolytic behavior in vitro, considering
their potential application as drug delivery systems.
Equilibrium swelling studies were carried out in enzymefree
simulated gastric and intestinal fluids (SGF and SIF;
pH 8 and pH 1, respectively). A model drug, olsalazine (an
azo derivative of 5-aminosalicylic acid), was entrapped in
these gels, and their in vitro release profiles were established
separately in SGF and SIF at 37 °C. The swelling and drug
release profiles revealed that the amount of drug released and
swelling of the hydrogels depended on the methacrylic acid
content and the crosslinker type and content.
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