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Abstract
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Nalidixic acid (NA) was intercalated into zinc hydroxide nitrate (ZHN) by an ion exchange method. The
resultant nanocomposite showed a basal spacing of 11.74 Å that corresponds to a pure phase,
confirmed by powder X-ray diffraction (PXRD) studies. The arrangement of NA in the interlayer of ZHN
was in a monolayer form. A FTIR spectroscopy study showed that the intercalation took place without
any change in the structure of NA and the thermal analysis results showed that NA is stabilized in
the interlayers by electrostatic interactions. Biocompatible NA–ZHN/chitosan nanocomposites were
prepared by coating of the NA–ZHN nanocomposite with chitosan and the drug release behavior in vitro
was studied. The antibacterial activities of the nanocomposite were tested against microorganisms. The
results showed that the synthesized nanocomposites show good inhibition against two Gram-positive
and Gram-negative species. NA–ZHN can prevent the growth of harmful bacteria more effectively than
the NA drug.
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