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Abstract
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The intercalation of fluoroquinolone antibiotic,
Gemifloxacin (GEM) anions, into layered zinc hydroxide
(LZH) has been achieved by using ion-exchange method.
The GEM-LZH/Chitosan nanocomposite coating Chitosan
nanocomposite was prepared in alkaline aqueous solution.
Powder X-ray diffraction studies confirmed a basal spacing
of 25.54 A ° , showing that the GEM was successfully
intercalated into the LZH interlayer. The arrangement of
GEM anions was in a monolayer form between the LZH
interlayers. Fourier transform infrared spectroscopy results
exhibited the formation of the host–guest nanohybrid
without any change in the structure of the GEM. The
increased thermal stability of nanohybrid was confirmed by
thermal analyses. The in vitro release study of GEM from
nanohybrid and nanocomposite was investigated in phosphate
buffer saline solution of pH 4.8 and 7.4 using
ultraviolet–Visible spectroscopy.
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