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Abstract
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The intercalation of amoxicillin trihydrate (AMOX) into layered zinc hydroxide
(LZH) has been achieved via ion-exchange method. The resulted nanocomposite
(AMOX-LZH) has been thoroughly characterised by a number of techniques
including powder X-ray diffraction (PXRD), FT-IR spectroscopy, TGA/DTG
analysis and scanning electron microscopy (SEM). The PXRD results showed
that the gallery height of LZH was expanded from 9.57 to 11.97 A
, indicating that
the AMOX anions were successfully intercalated into the interlayer space of
LZHs. The increased thermal stability of nanocomposite was confirmed by TGA/
DTG analyses. Improved antibacterial activity and minimum inhibitory
concentration of AMOX-LZH nanocomposite was evaluated against Grampositive
bacteria Staphylococcus aureus, Klebsiella pneumonia and Gram- negative
Escherichia coli using the disk diffusion technique. The sustained release of
amoxicillin drug from the AMOX-LZH nanocomposite was also verified.
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