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Abstract
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The anti-inflammatory drug, Diclofenac (DIC)
anion, was intercalated into the layered zinc hydroxide
(LZH) by ion-exchange method. Then, the DIC–LZH/
Chitosan nanocomposite was prepared by coating of
Chitosan on DIC–LZH. LZH intercalated with DIC was
successfully encapsulated into Chitosan by precipitation
method. The structures of the obtained products were
studied by powder X-ray diffraction, FT-IR spectroscopy,
scanning electron microscopy, and thermal analysis. The
XRD patterns and FTIR analyses showed that the DIC was
successfully intercalated into the LZH interlayer space with
an average basal spacing of 29.42 A ° . Thermal analysis
studies confirmed that the thermal stability of DIC was
enhanced after intercalation into LZH. In addition, drug
release behaviors in vitro of DIC from DIC–LZH and DIC–
LZH/Chitosan nanocomposites were observed in phosphate
buffer solution under the conditions of pH 4.8 and 7.4,
respectively.
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