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Abstract
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In this investigation, unsubstituted pyrazolin-3(5)-ones (MePzO= 3-methyl-5-
pyrazolone, PrPzO= 3-propyl-5-pyrazolone and PhPzO= 3-phenyl-5-pyrazolone)
have been synthesized. The synthesized compounds were also screened
for their antibacterial activity against some Gram-positive and Gram-negative
bacteria using agar well diffusion method. The compounds with different
concentrations were prepared and the activity was determined by measuring
the diameter of the inhibition zone (in mm). The minimum inhibitory
concentration (MIC) and minimum bactericidal concentration (MBC) of the
compounds were determined against six bacteria. The antibacterial activities
were influenced functional groups (methyl, propyl and phenyl). PhPzO
exhibited the strongest activity (MIC, 0.625 mg/mL; MBC, 2.5 mg/mL) against
Bacillus subtilis.
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