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Keywords
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,Salvia spinosa, Caryophyllene oxide, Spathulenol α-glucosidase Aldehyde oxidase, Xanthine oxidase
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Abstract
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The antimicrobial, antioxidant, brine shrimp toxicity and enzyme inhibitory activities of the essential oil and extracts of Salvia spinosa were investigated. GC-FID and GC-MS analysis of the essential oil resulted in identification of 19 compounds representing 98.5% of the oil. The major compounds of the essential oil were identified as caryophyllene oxide (63.0%), spathulenol (23.0%), linalool (3.9%) and trans-caryophyllene (3.0%). Essential oil showed strong aldehyde oxidase inhibitory activity with IC50 value of 40 g/ml. Methanol extract displayed the strongest DPPH radical scavenging, brine shrimp toxicity and α-glucosidase inhibitory activities. Total phenolic and flavonoid contents of the plant extracts were 36–
377 mg GAE/g and 13–134 mg QE/g, respectively. Methanol extract exhibited high amounts of phenolic and flavonoid compounds. The results showed that S. spinosa has great potential for several uses in food and pharmaceutical industries
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