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Keywords
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Diaminoglyoxime, Nitrones, 1,2,4-Oxadiazol, Quinazolinone, Rearrangement, Acetic acid, Cyclization
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Abstract
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Various 2-[5-(aryl)-1,2,4-oxadiazol-3-yl] quinazolin-4(3H)-ones have been synthesized from the reaction of diaminoglyoxime-based nitrones with methyl 2-aminobenzoate or 2-aminobenzamide in the presence of acetic acid at 100 ◦C. The reaction was extended as a one-pot three-component approach starting from diaminoglyoxime, aldehyde and methyl 2-aminobenzoate
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