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Abstract
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The objective of this study is to utilize the pH sensitivity of modified mesoporous silica nanoparticles
(MSN) for oral drug delivery. In the first time, a pH-sensitive ionic liquid was synthesized through the
quaternization of 3-aminopropyltrimethoxysilane (3-ATMS) with sodium monochloroacetate (SMCA).
Then, silica nanoparticle was modified by this pH-sensitive ionic liquid and converted to a pH-sensitive
positive-charge silica nanoparticle (PCSN). The nanoparticle was characterized by FTIR and SEM.
Naproxen as anionic drug molecules was entrapped in this pH-sensitive positive-charge silica
nanoparticles (PCSN) and the in vitro release profiles were established separately in both (SGF, pH 1) and
(SIF, pH 7.4).
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