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Keywords
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Ellagic acid, Reactive oxygen species, Hemoglobin, Methyl tert-butyl ether, Chemiluminscenc
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Abstract
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Ellagic acid (EA) has been gaining a considerable attention in recent years. The interest in non-drug and
herbal base therapies is being increased. EA is a biological molecule found in different fruits and seeds,
which is known to have the ability to scavenge reactive oxygen radicals. It has been observed that methyl
tert-butylether (MTBE) has destructive effects on structure and function of hemoglobin (Hb), an
important respiratory blood protein. This conclusion is reached from our far-UV circular dichroism, Soret
band absorption, fluorescence and oxygen affinity measurements. It has also been observed from our
chemiluminscence measurements that ROS production is increased in the presence of MTBE which
degrades heme in Hb. The main goal of this study was to offer a way to scavenge ROS produced during
MTBE interaction with Hb. We report that EA decreased the heme degradation and ROS production in Hb
solutions containing MTBE.
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