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Keywords
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Salvia, diabetes mellitus, alzheimer, antioxidant, antimicrobial, phenolic compounds.
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Abstract
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Abstract: Background: Salvia species are used traditionally for treatment of manydisorders all around the world. Salvia santolinifolia is a medicinal plant, traditionally used for treatment of inflammation, hypercholesterolemia, hemorrhoids and diarrhea. Methods: In this study, antibacterial, antioxidant, toxicity, acetylcholinesterase and - glucosidase inhibitory activities of several extracts of S. santolinifolia were evaluated. Total phenol and flavonoid contents of the extracts were also determined. Results: The MeOH extract showed high antioxidant activity in DPPH scavenging and ferric reducing power assays. All samples exhibited high acetylcholinesterase (IC50 = 42-89 g/ml) and -glucosidase inhibitory activities (IC50 = 24-174 g/ml). The MeOH extract showed great antibacterial and antifungal activities especially against Bacillus cereus and Candida albicans with MIC values from 10 to 200 g/ml. Conclusion: Our findings indicated that S. santolinifolia is a rich source of natural compounds with strong antimicrobial, antidiabetic and anti-Alzheimer activities. This plant has great potential for several applications as pharmaceuticals and functional foods.
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