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Keywords
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Salvia syriaca, Acetylcholinesterase, Alzheimer's disease, Docking study, β-sitosterol, Daucosterol
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Abstract
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Several Salvia species have been used to enhance memory in European traditional medicine. Accordingly, we
aimed to evaluate the acetone extract of the roots of Salvia syriaca for anti-Alzheimer constituents. Structures
of purified compounds were determined as ursolic acid, corosolic acid, β-sitosterol, urs-12-en-2α,3β-diol and
daucosterol (1–5). β-sitosterol and daucosterol exhibited high acetylcholinesterase inhibitory activities (24.1
and 34.3 μg/mL, respectively). The experimental results were also confirmed by docking analysis.
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