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Keywords
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Cellulose nanofiber, Poly vinyl alcohol, Hydrogel, Cisplatin, Drug delivery
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Abstract
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Delivery of chemotherapy drugs, such as cisplatin, with controlled manner is a significant area of research in
cancer treatment. The main purpose of this study was to investigate the in-vitro release of cisplatin from pH sensitive and
controlled release hydrogels based on cellulose nanofibers (CNFs) and poly(vinyl alcohol) (PVA). Various hydrogels with
different amounts of CNFs were prepared. This novel drug delivery system was characterized by Fourier transform infrared
spectroscopy (FT-IR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) analyses. By in-vitro experiments
the influence of CNFs contents and pH of the release media on the release rate of the drug were investigated. According to the
results, the hydrogel containing 1 wt% CNFs in the release media with the pH of 7.4, efficiently sustained the drug release
and so can cause to the reduction of side effects of drug. By fitting the experimental data with various kinetic models it was
concluded that the release mechanism is best fitted by Korsmeyer-Peppas kinetic model suggesting the diffusion controlled
release mechanism. The prepared hydrogel system is suitable for delivery of cisplatin in the small intestine with a controlled
manner.
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