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Abstract
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Background: The thyroid cancer (TC) is one of endocrine malignancies which contributes to more than 50% of all deaths from
endocrine cancers. Gene polymorphisms including DNA repair genes such as XRCC1 (X-ray repair cross-complementing group 1)
gene are thought to modify DNA repair capacity and relate to cancer risk.
Objectives: The aim of the study was to detect the association between XRCC1 polymorphisms and increased risk of thyroid carcinoma
among Iranian-Azeri patients.
Methods: This case-control study was performed on 114 differentiated thyroid carcinoma patients and 91 normal control subjects.
Single nucleotide polymorphisms (SNPs) of 194 C > T and 399 G > A of XRCC1 gene were genotyped by polymerase chain reactionrestriction
fragment length polymorphism (PCR-RFLP).
Results: In the present study, polymorphism at codon 194 of the XRCC1 gene was not found in case and control groups (P = NC (not
calculated). All of the case and control subjects were 194C/C. Unlike 399 G > A genotype (P < 0.001, OR = 0.184, CI = 0.09 - 0.372), there
was a positive association for 399G/G (P < 0.001, OR = 3.304, CI = 1.624 - 6.780) and 399 A/A (P < 0.001, OR = 14.143, CI = 1.861 - 296.277)
genotypes with differentiated thyroid carcinoma. The frequency of variant 399 A allele among the cases was slightly higher than
that in controls (P = 0.269, OR = 0.798, CI = 0.535 - 1.190).
Conclusions: Based on these results, the XRCC1 399G> A genotype could be used as a useful molecular biomarker to predict genetic
susceptibility for differentiated thyroid carcinoma in Iranian-Azeri patients.
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