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Title
Novel antibacterial polymeric nanocomposite for smart co-delivery of anticancer drugs
Type of Research Article
Keywords
Antibacterial polymers; combination therapy; dual anticancer drug; sustained release; stimuli responsive; nanocomposite
Abstract
Here a novel antibacterial nanocomposite was developed for combination cancer therapy. The synthesized nanocarrier was characterized by FTIR, 1H NMR, thermogravimetric analysis (TGA), and FESEM-EDX. Its antibacterial activity was assessed by determining minimum inhibitory concentration (MIC) values. Doxorubicin (DOX) and methotrexate (MTX) conjugation with nanocarrier sustained the release of both drugs with apparent pH-triggered manner. Co-administration of DOX with MTX leads to an efficient anticancer performance to MCF7 cell lines verified by qRT-PCR and MTT assay tests. It was concluded that this novel drug delivery vehicle makes antibacterial and anticancer therapeutic processes proceed spontaneously, representing more efficient drug delivery system in nanomedicine.
Researchers Elham Zakerzadeh Zakerzadeh (First Researcher)، Effat Alizadeh (Second Researcher)، hossein samadi kafil (Third Researcher)، Azad Mohammad Hassanzadeh (Fourth Researcher)، Roya Salehi (Fifth Researcher)، Mehrdad Mahkam (Not In First Six Researchers)