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Abstract
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Nanohybrid systems based on carbon nanotubes and pH-sensitive poly(methacrylic acid) were
prepared through attaching polymer chains onto carbon nanotubes. First, polymerizable groups
were attached onto carbon nanotube walls, then the polymerizable groups were copolymerized
with different ratios of methacrylic acid. Obtained systems were studied and characterized through
Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy,
and transmission electron microscopy. A model drug (naproxen) was entrapped into the prepared
materials and in vitro release studies were performed in pH 1 (simulated gastric fluids) and pH 7.4
(simulated intestinal fluids). It was noticed that release in simulated intestinal fluids was faster
than simulated gastric fluids, therefore the prepared nanohybrid systems can be considered as
appropriate carriers for colon-specific drug delivery.
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