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Abstract
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The MCM-41-based nanocomposite was synthesized via in situ copolymerization
of functionalized MCM-41 (polymerizable MCM-41) with
methacrylic acid (MMA). To prepare nanocapsules, the synthesized nanocomposite
was treated with hydrofluoric acid (HF) and as a result the MCM-41 was removed.
These pH-sensitive materials were characterized by FT-IR, EDX and SEM, also
their structure and the role that MCM-41 plays were investigated. Naproxen, as a
model drug, was entrapped into these drug carriers and the in vitro release profiles
were established separately in both enzyme-free simulated gastric (SGF, pH 1) and
simulated colonic fluids (SCF, pH 7.4). The release rates at SCF were higher than
that of SGF. In addition, study shows that the silanol groups of MCM-41 play a role
in drug entrapment efficiency.
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