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Abstract
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Anni ioc liquid monomer, 3-methyl-1-[2-(2-methyl-acryloxy)-
ethyl]-imidazolium chloride, was synthesized
through the quaternization of N-methylimidazole and
2-chloroethyl methacrylate. This ionic liquid monomer
intercalated into the montmorillonite layers and subsequently
copolymerized with methacrylic acid. The
organic–inorganic composite was characterized by
FTIR, XRD, SEM, and EDX to study their structure and
properties. Naproxen as a model drug was entrapped
in these pH-sensitive positively charged nano carriers
and the in vitro release profiles were established separately
in both enzyme-free simulated gastric and intestinal
fluids (SGF, pH 1) and (SIF, pH 7.4) respectively. It
was observed that the drug release percentages in SIF
were higher; hence the prepared nanocomposite could
be considered as a suitable carrier for colon specific
drug delivery. POLYM. COMPOS., 00:000–000, 2014. VC 2014
Society of Plastics Engineers
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