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Abstract
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The main objective of this work was chemically bioactivation of the conducting polyanizidine (PANIZ) by
incorporating a polyester such as polycaprolactone (PCL). Modified PANIZ nanocomposites were synthesized through ring
opening and chemical oxidation polymerizations. A four-point probe was applied to measure the conductivity of newly
synthesized star-like block copolymer (S-PCL-PANIZ) nanocomposite, which was about 0.44 S cm-1. Conductive
biodegradable nanofibers were prepared by electrospinning with 25 and 75 % (wt/wt) S-PCL-PANIZ to PCL. The contact
angle of each prepared nanofiber was 87±3 o, supporting their usefulness for cell culture. The cultured mouse osteoblast
MG63 cells demonstrated normal morphology and significantly higher adhesion and spreading on the nanofiber. The
bioactivated PANIZ based nanocomposite may be fruitful in tissue engineering to fabricate conducting biodegradable
scaffolds with improved cell adhesion properties for various cell cultures.
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