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Abstract
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In the present work, a novel magnetic and pH-responsive porous nanocomposite was prepared by the surface grafting of β-cyclodextrin onto Fe3O4@Silica@MIL-100 (Fe). The effect of pH and temperature on adsorption of cephalexin and release behavior of the developed nanocomposite was studied. It was found that the maximum adsorption occurs at room
temperature while the fast release occurs at higher temperature. Among different two- parameter isotherm models, the results showed that the adsorption of drug was well described by Langmuir isotherm model. Different kinetic models including Film-transfer, intra-particle diffusion, and pseudo-second order kinetic models were used to investigate the mechanism of adsorption. Thermodynamic studies indicated that the adsorption of cephalexin onto the nanocomposite was exothermic and spontaneous. In addition, the nanocomposite showed sensitive pH-dependent behavior. Finally, mathematical kinetic models such as zero-order, first- order, Korsmeyer- Peppas and Higuchi were studied to investigate the drug release profile where kinetic of release was well described by Higuchi model.
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