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Abstract
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Fe3O4 magnetic nanoparticles were then modified by carbon via a simple hydrothermal method by using glucose.
The synthesized Fe3O4 and carbon-coated Fe3O4 (C/Fe3O4) magnetic nanoparticles were characterized by
diverse techniques such as XRD, FESEM, EDX, FTIR, and BET. The characterization results were confirmed the
formation of the uniformly magnetic nanoparticles and a successful modification of them by carbon. The FTIR
spectra confirmed the presence of functional groups on the C/Fe3O4 magnetic nanoparticles surface. The
magnetic nanoparticles were used for extraction of losartan, carvedilol, and amlodipine besylate from plasma
samples based on magnetic solid phase extraction (MSPE) technique. The effective parameters on extraction
efficiency were optimized by multivariate optimization. Under the optimized experimental conditions the MSPE
method showed wide linear ranges (1–7500 ng mL−1), low detection limits (0.09–0.69 ng mL−1), good extraction
recoveries (56.35–66.43%), and low RSD values (1.6–5.8%). Despite high protein binding of the drugs, the
analyses of them were done without protein precipitation. The accuracy was studied by analyses of the spiked
plasma samples at different concentrations.
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