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Abstract
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For the first time, nano carboxymethyl cellulose (NCMC) was synthesized via cellulose nanocrystal
carboxymethylation. This nanomaterial was magnetized and used in bilayer alginate-chitosan hydrogel beads
formulation to develop eco-friendly, smart, and magnetic sensitive hydrogel beads for the controlled pHsensitive
release of dexamethasone as a model drug.Water-soluble nanocrystalline cellulose (NCMC) and bilayer
hydrogel beads were characterized in terms of size, surfacemorphology, surfacemodification, crystallinity, drug
loading content, and in vitro drug release profile using various technics. Furthermore, the swelling behavior of
hydrogels was examined and reported in three buffer media. The NCMCs improved drug loading capacity and
swelling properties and also regulated drug release behavior of hydrogels. The hydrogel beads swelling specification
exhibited a higher index in phosphate buffer at pH 5.8 than at pH 1.2 and 7.4. Besides, in vitro release of
beads revealed excellent pH-sensitive drug release profiles and prevented release in the gastrointestinal tract.
The beads showed high pH sensitivity for dexamethasone drug in pH 5.8 in compared to other pHmedia. The obtained
results could introduce hydrogel beads as a high potential drug delivery system.
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