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Title
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A novel bio-inspired conductive, biocompatible, and adhesive terpolymer based on polyaniline, polydopamine, and polylactide as scaffolding biomaterial for tissue engineering application
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Abstract
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A novel electrically conductive nanofibrous scaffold based on polyaniline-co-(polydopaminegrafted-
poly(D,L-lactide)) [PANI-co-(PDA-g-PLA)] was fabricated using electrospinning
technique and its physicochemical as well as biological characteristics toward bone tissue
engineering (TE) were investigated extensively. In detail, PANI-co-PDA was synthesized via a
one-step chemical oxidization approach. Then, D,L-lactaide monomer was grafted onto PDA
segment using a ring opening polymerization (ROP) to afford PANI-co-(PDA-g-PLA)
terpolymer. The successful synthesis of PANI-co-(PDA-g-PLA) terpolymer was confirmed using
FTIR spectroscopy as well as TGA analysis. Finally, a solution of the synthesized terpolymer
was electrospun to fabricate a conductive nanofibrous scaffold. Some physicochemical features
such as mechanical, conductivity, electroactivity, hydrophobicity, and morphology as well as
biological characteristics including biocompatibility, biodegradability, as well as enhancing the
cells adhesion and proliferation were investigated. According to the above-mentioned
experimental results, the fabricated electrospun nanofibers can be considered as a potential
scaffold for TE application, mainly due to its proper physicochemical and biological properties.
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