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Abstract
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Aims: Chronic wounds, such as pressure sores and diabetic ulcers, because of their prolonged
healing process, have been a difficult topic for wound dressings. The aim of this study was to
develop a bio-active dressing based on polymers and natural materials with unique biological
and therapeutic properties. The bio-active dressing is based on polymers and natural materials
with unique biological and therapeutic properties.
Methods: The dressing was composed of an active layer containing polyvinyl alcohol (PVA),
honey, curcumin, and keratin, and an upper layer with less hydrophilicity comprising PVA to
induce flexibility. Physicochemical properties of the dressings were characterized by Fourier
Title page
transform infrared spectroscopy, field emission scanning electron microscopy, swelling
behavior, and antibacterial measurements. Wound healing study was performed using an
experimental rat model and two different compositions of the dressing were compared to
commercial wound dressing. Histopathological evaluation was conducted for this purpose.
Results: Characterization results showed that smooth bilayer film with two homogenous
distinct layers was produced. The dressing also provided adequate moisture to the wound
environment without infection and adhesion due to dryness. Our results exhibited significant
bactericidal activity against gram negative (E. coli) and gram positive (S. aureus) bacteria and
improved wound healing process without any scarring. Histopathological findings
demonstrated a significant higher healing rate in vivo together with well-formed epidermis,
granulation tissue formation, and tissue contraction, when compared to the commercial wound
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