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Abstract
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Inorganic-organic hybrid materials possess multi-functionalities with noteworthy properties due to the combination of their counterparts. These materials may find significant application in biomedical technology, specifically in drug delivery process [1]. In this regard, micro and mesoporous inorganic products, such as zeolites, have been largely used as adjuncts to polymeric substances in a variety of forms, such as composites, blends, and hydrogels for drug delivery [2, 3]. The objective of this study was to develop an inorganic-organic hybrid material based on zeolite and alginate for sustained release of an anticancer drug to improve its half-life. For this purpose, first drug was loaded on zeolite pores by soaking and mixing procedures. Then, hybrid hydrogel beads, composed of zeolite-drug core coated with alginate shell were prepared by using in-situ gel preparation technology. The prepared drug delivery system was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and scanning electronmicroscopy (SEM) analyses. By in vitro experiments the effects of zeolite contents and pH of the release media on the release rate of the drug were investigated. According to the results, the inorganic-organic hybrid hydrogels showed an improved encapsulation efficiancy (EE) and drug loading content (DLC). The swelling of hydrogels showed a pH-responsiv behavior in three buffer media. Finally, in vitro drug release studies revealed the delivery of anticancer drug with a controlled manner.
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