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Abstract
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Vinyl chloride is a colorless gas with a pleasant odor capable of entering the body through oral or inhalation routes. Extensive
studies on this compound indicated that it is a carcinogen, and Vinyl chloride exposure can result in a specific type of cancer
in vinyl chloride workers. Whereas hemoglobin plays a vital role in oxygen transfer throughout the body, in a molecular
aspect, the effect of vinyl chloride on human hemoglobin has not been studied. Furthermore, selenium as an antioxidant is
a vital factor for the health of humans and animals. Then this research investigated the effect of the antioxidant capability
of selenium at the same concentrations in blood on the interaction between vinyl chloride and hemoglobin. UV–visible,
Fourier-transform infrared, chemiluminescence, and fluorescence spectroscopies were employed. The results indicated the
destruction of hemoglobin structure in different concentrations of vinyl chloride. At the same time, the antioxidant effect of
selenium inhibited the destructive impact of vinyl chloride on hemoglobin structure.
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