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Abstract
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Since amphetamine-type stimulants (ATS) drugs have been approximately abused by 24.7
million people [1], there is a growing global demand for the selective trace amount measuring them in the
biological fluids. Methamphetamine (MAMP) is one of the famous industrial opiates. Its excessive
consumption disrupts the function of the brain neurotransmitters and increases heart rate, respiratory
problems and even worse, may lead to stroke and death [2]. So, sensitive MAMP detection in the biological
and street samples is vital for several organizations such as forensic medicine, anti-drug headquarters and
diagnostic clinics. We fabricated a glassy carbon electrode (GCE) modified with nanodiamond-derived
carbon nanoonions (CNOs) and silver nanodendrites (AgNDs), denoted as the AgNDs/CNOs/GCE, as the
sensor for MAMP detection. The electron dispersive X–ray analyzer (EDX) and X-ray diffraction patterns
(XRD) techniques confirmed the presence of the applied elements as the modifier on the surface. SEM
images of the embedded sensing interface revealed a unique distribution of the dendritic structures similar
to tree foliage on the GCE surface. The sensing interface presented a high surface area, more conductivity
and excellent capability for MAMP catalysis compared to the bare GCE. MAMP was quantitatively
detected under two broad concentration ranges from 99 nM to 7.48 μM and 7.48 μM to 59.88 μM with a
limit of detection (LOD) of 30 nM. The sensor feasibility in MAMP monitoring was satisfactorily
evaluated by analyzing some human blood serum and urine specimens.
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