|
Abstract
|
In the current research, vancomycin loaded-mesoporous bioglass/hydroxyapatite whiskers/chitosan composite coatings with drug delivery capability were fabricated on titanium substrate via electrophoretic deposition. Hydroxyapatite with whisker morphology demonstrated improvement in microhardness of the coatings. Among different initial vancomycin concentrations of 1, 5, 15, 25 and 50 mg/ml to load mesoporous bioglass particles, maximum loading efficiency and drug content (95%) were achieved at 25 mg/ml. Based on the quality of the coatings, bioglass loaded with initial concentrations of 1, 5 and 15 mg/ml drug were chosen as optimal samples for further investigations. Synergistic effect of bioglass and hydroxyapatite caused the composition with 20% and 50%Wt MBG to have faster bioactivity response. Regarding the drug delivery capability of the composite coatings, sample containing 50%Wt bioglass encapsulated with 15 mg/ml drug exhibited rapid and maximal drug release due to the facile diffusion of the solved bioglass particles. The achieved results showed the acceptable antibacterial potency of vancomycin-loaded coating to prevent infection. Moreover, existence of antibiotic did not have any toxic effect over the osteoblast cells cultured on the coatings.
|