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Abstract
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Viruses have always been the concern of human societies, The threat of emerging RNA-viruses spreading further demands for the development of potent therapeutic agents with activities against a broad range of such pathogens.1,4-Pyrazine-3-carboxamide-based antiviral compounds have been under intensive study for the last 20 years. One of these compounds, favipiravir (6-fluoro-3-hydroxyl pyrazine-2-carboxamide,T-705),that exhibits antiviral activities against a variety of RNA viruses and is approved for use against the influenza infection in a number of countries. In recent years,favipiravir actively used against COVID-19. In order to propose compounds with new antiviral properties, we designed and synthesized a new class of 3-hydroxy-5-aryl-pyrazine-2-carboxamide derivatives using 2-Aminopropanediamide and arylglyoxal derivatives under reflux conditions with a short duration and using green water solvent.The compounds were characterized by 13C NMR, 1H NMR, and IR. Therefore, the development of a short and eco-friendly approach using non-toxic reagents and solvents is highly desirable. The present work proves to new insights for develop new drugs using Based on favipiravir in the treatment of virus.
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