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Keywords
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Indole–acrylonitrile hybrids, indole-coumarin hybrids, aqueous media, domino reaction, anti-inflammatory, organic
solvents.
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Abstract
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Indole–acrylonitrile hybrids were synthesized via a catalyst-free reaction of aromatic aldehydes
and 3-(cyanoacetyl)indole in aqueous media. Also, indole-coumarin hybrids were synthesized
via a domino reaction of salicylaldehyde derivatives and 3-(cyanoacetyl)indole in the presence
of ammonium acetate in aqueous media. The advantages of the present protocol are high yields,
short reaction times, mild reaction conditions, operational simplicity, and environmentally benign,
and also there is no need to purification of products.
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