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Abstract
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A one-step procedure has been developed for the synthesis of new Hantzsch poly-substituted pyridines from a three-component
reaction of N-(adamantan-1-yl)acetoacetamide, aldehyde derivatives, ammonium acetate in ethanol in the presence
of montmorillonite K10 catalyst under reflux conditions. The presence of adamantyl moiety in adamantyl acetoacetamide
as an active methylene component leads to a strong steric hindrance and accelerates the oxidation of 1,4-dihydropyridines
to the pyridine derivatives. The use of montmorillonite catalyst leads to a simple procedure of synthesis and short reaction
times. As a result, facile workup, simple reaction procedure, good yields, and economical process are advantages of this
one-pot multicomponent reaction.
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