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Abstract
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In this research, a novel macrocyclic ligand was prepared by hydrogenation tetra aza macrocyclic and coupling
with the 2-chloro-benzimidazole derivatives. The new metal-organic frameworks (MOFs) were synthesized by a
reaction of Cu (II) ion with macrocyclic ligand (copper-macrocyclic organic framework (Cu-MMOFs)). The
synthetic compound fully characterized by various analysis techniques. In electrochemical studies, Cu-MMOFs
were employed as excellent modifiers on the surface glassy carbon electrode (GCE) with Nafion (NF) as (CuMMOFs/Nf/GCE) modified electrode to investigate the analytical performance of digoxin (DIG) with different
electrochemical methods to clarify the electrocatalytic properties of DIG in phosphate buffer (PBS) solution. The
diffusion coefficient (DDIG = 1.38×10− 6 cm2 s
− 1
) and catalytic rate constant (kcat = 0.287×106 cm3 mol− 1 s
− 1
)
were estimated for the oxidation of DIG at the surface of modified electrode. Under the optimal condition, the CuMMOFS/Nf/GCE displays a good electrochemical nature for DIG in the 0.019–38 μM range, with a low limit of
detection (LOD) 0.0158 µM (S/N = 3) and a great reproducibility, repeatability and admirable selectivity.
Additionally, the fabricated sensor exhibited excellent performance by measuring the concentration of DIG in
real samples (such as human blood serum samples), which proves the potential of Cu-MMOFS/Nf/GCE for
practical applicability with good favorable recoveries (100.35 %).
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