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Abstract
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It has been a great challenge to develop suitable tissue adhesives that can be efficient on wet internal tissues with acceptable adhesion strength and biocompatibility. Chitosan-based hydrogels have been widely used in biomedical applications owing to their versatile properties. To this end, we have devised the functionalization of chitosan with gallic acid (GA, L-DOPA analogue) and in turn, the formation of a cross-linked network with a dialdehyde cellulose nano crystal (DACNC) to obtain an efficient bio adhesive material. To provide a bacterium–free environment that improves the healing process, zinc oxide nanoparticles (ZnO NPs) were incorporated into the chitosan-catechol matrix. The structural characteristics of films using FTIR confirmed successfully formation of hydrogels. The addition of ZnO enhanced the antimicrobial peroperties of the hydrogels. Functional properties of the hydrogels such as physiological stability assessment, in vitro blood-clotting performance, cytocompatibility, adhesive strength, and hemostatic performance will be investigated.
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