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Abstract
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Molecularly imprinted polymers (MIPs) have garnered the interest
of researchers in the drug delivery due to their advantages, such
as exceptional durability, stability, and selectivity. In this study, a
biocompatible MIP drug adsorption and delivery system with high
loading capacity and controlled release, was prepared based on
chitosan (CS) and graphene quantum dots (GQDs) as the matrix,
and the anticancer drug oxaliplatin (OXAL) as the template.
Additionally, samples without the drug (non-imprinted polymers,
NIPs) were created for comparison. GQDs were produced using the
hydrothermal method, and samples underwent characterization
through FTIR, XRD, FESEM, and TGA. Various experiments were
conducted to determine the optimal pH for drug adsorption, along
with kinetic and isotherm studies, selectivity assessments, in vitro
drug release and kinetic evaluations. The highest drug binding
capacity was observed at pH 6.5. The results indicated the
Lagergren-first-order kinetic model (with rate constant of
0.038 min−1) and the Langmuir isotherm (with maximum adsorption
capacity of 17.15 mg g−1) exhibited better alignment with the
experimental data. The developed MIPs displayed significant selectivity
towards OXAL, by an imprinting factor of 2.88, in comparison
to two similar drugs (cisplatin and carboplatin). Furthermore, the
analysis of the drug release profile showed a burst release for
CS-Drug (87% within 3 h) at pH 7.4, where the release from the
CS-GQD-Drug did not occur at pH 7.4 and 10; instead, the release
was observed at pH 1.2 in a controlled manner (100% within 28 h).
Consequently, this specific OXAL adsorption and delivery system
holds promise for cancer treatment.
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