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Abstract
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Riluzole is an important drug in the management of ALS because it prolongs the survival of patients; hence, its precise measurement is an important issue in pharmacokinetic studies and therapeutic monitoring. Low drug concentrations in biological fluids, along with complicated matrix features, make the analysis difficult in both biological and environmental condition. Most methods reported so far failed to attain an ideal compromise between sensitivity, precision, and cost; hence, new techniques are warranted. Some of the drawbacks of the above-mentioned techniques could be partially overcome by the use of 3D printing technology for the fabrication of cost-effective and highly flexible fibers. The possibility to control morphology and functionalization of those fibers increases properties related to the recovery of analytes and selectivity. Besides, the use of sustainable material with low solvent consumption joins the efforts toward green analytical chemistry pursued all over the world.
Results obtained within the framework of this study can largely contribute to the enhancement of drug monitoring functions, reduction of analytical costs, and development of 3D printing use in environmental and pharmaceutical research.
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