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Abstract
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BACKGROUND: The CYP2D6 gene locus is complex and highly polymorphic. Given the
clinical importance of the CYP2D6 enzyme in liver xenobiotic metabolism, genotyping its
significant alleles among different ethnic groups is essential for evaluating the efficacy
of certain drugs. In this study, we assessed the frequency of the CYP2D6*4, *9, *10, and
*41 alleles in a healthy population from northwestern Iran.
METHODS: Fifty unrelated healthy individuals from West Azerbaijan Province, Iran, were
studied using PCR-RFLP and ARMS-PCR techniques.
RESULTS: CYP2D6*9 (rs5030656) allele was not detected. The frequency (%) of CYP2D6*4
(rs3892097), CYP2D6*10 (rs1065852) and CYP2D6*41 (rs28371725) alleles were 10%,
13% and 8%, respectively.
CONCLUSION: Our findings indicate that the frequencies of “non-functional” and
“reduced function” alleles are relatively high in this population. Determining Cytochrome
P450 2D6 allele variations can contribute to risk assessment and patient management
regarding adverse or poor drug responses, ultimately aiding in the prevention of
increased mortality risks among different populations.
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