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Abstract
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In this paper, macrocycle compounds containing nitrogen and oxygen groups were synthesized via template
condensation of o-phenylenediamine with various aromatic dicarboxylic acids. In the following stage, to create
an appropriate linker for the formation of metal-organic frameworks (MOFs), the obtained macrocyclic compound
was reacted with 4-chloro 2-methylimidazole derivatives in a straightforward reaction. A new metalorganic
frameworks (MOFs) was formed by the interaction of Co (II) ions with a macrocyclic ligand, specifically
the Zeolitic imidazolate framework macrocyclic ligand metal-organic frameworks (ZIF-MLMOFs). The
synthesized compounds were thoroughly characterized using various physicochemical methods, including
melting point determination and elemental analysis techniques such as XRD, NMR, and FT-IR spectroscopy. The
results obtained were consistent with the proposed structures. In order to apply the synthetic material, the
electrochemical technique was used for investigation of Losartan (LOS) drug sample. Subsequently, the catalytic
activity of ZIF-MLMOFs/Nf/GCE was characterized by cyclic voltammetry (CV) and chronoamperometry (CA)
for the oxidation of LOS in PBs media. The diffusion coefficient of LOS was found to be (DLOS =7.94×10 6
cm2 s 1) and the catalytic rate constant was measured as (kcat = 1.75×106 cm3 mol 1 s 1). Differential pulse
voltammetry (DPV) exhibited a linear response range of 1.99–100 μM with a limit of detection of 0.76 μM. The
electrochemical sensor exhibited exceptional selectivity and sensitivity, along with reproducibility and repeatability,
which can enhance the application of MOFs in drug electrochemical sensors.
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