Research Management System دانشگاه شهید مدنی آذربایجان | Preparation of Nano Silca Supported Sodium Hydrogen sulfate: As and Efficient Catalyst for the Trimethyl, Triethyl and t- Butyldimethyl Silylations of Aliphatic and Aromatic Alcohols in Soultion and under Solvent-free Conditions

Title	Preparation of Nano Silca Supported Sodium Hydrogen sulfate: As and Efficient Catalyst for the Trimethyl, Triethyl and t- Butyldimethyl Silylations of Aliphatic and Aromatic Alcohols in Soultion and under Solvent-free Conditions
Type of Research	Article
Keywords	Silyl ethers; Phenolic drugs; TMSCl; TESCl; TBSCl; Nano silica; NaHSO4
Abstract	Nano silica-supported sodium hydrogen sulfate has been prepared by mixing NaHSO4 with activated Nano silicagel in solvent-free conditions. We wish to report a new method for the synthesis of trimethyl (TMS), triethyl (TES) and t-buthyldimethyl silyl (TDS) ethers from benzylic, allylic, propargilic alcohols, phenols, naphtoles and some of phenolic drougs in the presence of NaHSO4.SiO2(nano) / Et3N, in room temperature in excellent yields, both in solution and under solvent-free conditions. This procedure also allows the excellent selectivity for silylation of alcohols and phenols.
Researchers	Abdolreza Abri (First Researcher)، Somayeh Ranjdar (Second Researcher)

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