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کلیدواژهها
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fractional differential equations, Caputo fractional
derivative, cure rate, global stability, Lyapunov function, humoral immunity
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چکیده
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Infectious diseases pose a significant threat to global health, and
mathematical modeling can be highly useful for understanding their transmission
dynamics. Fractional differential equations have emerged as a powerful tool
for modeling complex systems with memory and long-term interactions. In this
paper, we provide a mathematical model of generalized viral infection with cure
rate via FDEs. The basic reproduction number will be obtained and positivity
and uniformly boundedness of solutions will be controlled. Three equilibrium
points: infection-free equilibrium, immune-free equilibrium and chronic equilibrium,
will also be calculated. It will be shown that the infection-free equilibrium
is globally asymptotically stable if the reproduction number is less than one and
if it is more than one, within certain conditions on humoral immune response
reproduction rate, then the immune-free and the chronic equilibria are globally
asymptotically stable. Finally, numerical simulations will be presented to
establish the analytical calculations.
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