مشخصات پژوهش

In recent years, 3D printing has received unprecedented attention in many fields of science and technology [1]. Due to its capability of rapid prototyping, reduced manufacturing time, one-step manufacturing, and development of various materials for 3D printing, its applications in the field of analytical chemistry have grown increasingly [2]. In this research, application of 3D printing technology for the development of solid-phase microextraction (SPME) and thin film microextraction (TFME) were studied and developed in four main sections. First, preparation of mixed matrix membrane thin film based on graphitic carbon nitride and acrylate photo-resins was carried out using a digital light processing (DLP) 3D printer and applied as TFME adsorbent in determination of estrone and 17-β-estradiol in water samples. The LODs for both analytes were 1.5 µgL-1 and the LDR was 5-150 µgL-1. In the second study, 3D printed SPME scaffolds was presented as a new tool for sample preparation. Designed cubic scaffolds based on biodegradable polylactic acid (PLA) with surface modification via alkaline treatment were used to extract ketoconazole, clotrimazole and miconazole. The LDR of the method was 10-100 µgL-1 for plasma samples and 10-150 µgL-1 for wastewater samples, respectively. The LODs were 3.10 µgL-1 in both samples. In the third study, a new thin film was made using PLA filament by FDM 3D printer and its surface was modified by atmospheric cold plasma (CAP). The proposed film was used as a new adsorbent for TFME of anticancer drugs including dasatinib and erlotinib from human plasma. The LODs and LDR of the method for dasatinib were 0.03 and 0.1-20 µgL-1, and for erlotinib were 0.3 and 1-500 µgL-1, respectively. In the fourth study, a hydrothermal method was performed to fabricate Co-Al LDH adsorbent on 3D printed aluminum-PLA composite to use as a SPME fiber. The proposed fiber was used for the extraction of six phenolic acids from the fruit juice samples including apple, r