مشخصات پژوهش

Pseudomonas aeruginosa is an opportunistic pathogen associated with a wide range of infections, particularly in immunocompromised patients. Its intrinsic resistance to antibiotics and its ability to form robust biofilms make it a major concern in clinical settings. The increasing prevalence of multidrug-resistant (MDR) and biofilm-forming strains poses significant challenges in treatment and infection control [1], [2]. Despite advances in antimicrobial therapy, infections caused by P. aeruginosa are becoming increasingly difficult to eradicate. The biofilm matrix acts as a physical barrier, and the expression of specific resistance and virulence genes further enhances its survival [2], [3]. Moreover, the misuse and overuse of antibiotics have exacerbated resistance mechanisms [4]. There is an urgent need to explore molecular mechanisms underlying resistance and biofilm formation, and to identify potential natural agents that may serve as alternative or adjunctive therapies [5], [6].