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Abstract
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Thyroid hormones are vital hormones involved in the regulation of metabolism, growth, as well as cellular energy production [1]. Thyroid dysfunction, either hypothyroidism or hyperthyroidism, is one of the top endocrine disorders that affects a large number of people around the world [1, 2]. Thyroid dysfunction is often related to disturbances in metabolism, oxidative stress, as well as several alterations in biochemical parameters like the lipid profile, liver enzymes, and antioxidant levels [3].
Coenzyme Q10, or ubiquinone, is a lipidsoluble compound that functions as an active component of the mitochondrial electron transport chain and a strong antioxidant [4]. It plays a crucial role in ATP production and maintaining cell membrane resistance to oxidative injury. Some studies have indicated that thyroid disturbances may influence the metabolism of coenzyme Q10, resulting in alterations of serum concentration levels [5]. Hypothyroid patients, for example, present with high levels of coenzyme Q10 due to reduced metabolism, whereas hyperthyroid patients present with lower levels due to enhanced oxidative metabolism and utilization of antioxidants [6].
However, in spite of all this evidence, the relationship between the level of CoQ10 and other biochemical indices in thyroidopathies is still unclear. Few studies have elucidated the relationship between differences in levels of CoQ10 and indices related to liver functions, lipids, and oxidative stress levels associated with various thyroid conditions [7]. Elucidating this could explain the significance of the potential indicator, CoQ10, related to oxidative disturbances among thyroidopathies.
Accordingly, the aim of this research is to examine the level of serum Coenzyme Q10 among patients with thyroid dysfunction as well as its relation to other selected biochemical tests. The proposed study may help to gain a better understanding about the pathophysiological mechanism involved among thyroid patients, as well as the
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